Observations that Organisms adapt their physiology and behavior to the time of the day in a circadian fashion have been documented for a long time and are commonly agreed to have begun with the observation of leaf and flower movements in plants. For example, the leaves of mimosa plants close at night and open during the day. In 1729, the French astronomer Jean Jacques d’Ortous de Mairan placed a mimosa plant in the dark and observed that the leaves still opened and closed rhy

These recent reports regarding the very high general prevalence of SDB and factors that influence the relationship with hypertension prompt a reassessment of the clinical relevance regarding the association between OSA and hypertension, especially nocturnal hypertension, and the underlying mechanisms that may contribute to the development of a non-dipping nocturnal blood pressure profile in OSA patients. This topic is important in the context of the recent SAVE (Sleep Apnea C

This randomized controlled clinical trial demonstrates that in the hands of sleep medicine specialists an integrated home-based portable monitoring strategy for both diagnosis and treatment of patients with moderate to severe OSA is not inferior to a laboratory-based strategy. The home-based strategy appears equivalent in terms of outcomes important to patients: acceptance of therapy, time to treatment, reduced hypersomnolence, improved functional outcomes (both generic and d

Our findings suggest that CBT-I may improve cognition among people with chronic HF and insomnia. Notably, the odds of improved self-reported cognition and less than 3 PVT-measured lapses in the CBT-I group were about twice the odds of improvement in the attention control condition, although there was only a significant group-time effect for the proportion with improvements in self-reported cognition. Although these findings must be interpreted cautiously and the study was not

Clinical studies have shown that levels of MPs of various cellular origins, including platelets, endothelial cells and leukocytes, are increased in OSA patients. Figure 1 illustrates the main antigenic epitopes harboured by MPs investigated in OSA patients. Levels of MPs harbouring markers of cellular activation or apoptosis that are known to predict poor cardiovascular outcomes were found to be correlated with OSA severity as well as markers of vascular impairment, and were

his study obtained sleep parameters and self-reported sleep status during both dPSG and tPSG. CPAP adherence in patients with OSA could be predicted by examining the changes in various indices with CPAP use. PSG evaluations demonstrated that CPAP adherence can be expected in patients who demonstrated improvements in AHI, sleep architecture, such as stage N1% and N3%, TST, sleep efficiency, and sleep latency with CPAP. These findings were correlated with self-reported sleep im

The hemodynamic benefits of MV are often-overlooked in patients with decompensated congestive heart failure and cardiogenic shock in particular. Favorable effects of MV in acute decompensated HF include reducing ventricular preload and afterload, decreasing extra-vascular lung water, and decreasing the work of breathing and its associated cardiac output requirements. The appropriate use of MV should be seen as an important adjunctive therapy in the initial stabilization and m

We have evaluated the RWD responses to PAP based on AHI reductions in 195 children with OSA. These analyses allowed us to define individual determinants of pediatric PAP responsiveness in a real-world setting. Our results showed that children have an adequate response to PAP therapy, with a median AHI reduction of 85% compared to baseline PSG results. We have also identified substantial heterogeneity of the PAP responses, with around 30% showing < 75% AHI reductions. Interest

Sleep disordered breathing and dysglycaemia are intimately linked, but the existence of an independent relationship between them, beyond their shared association with obesity, has been difficult to definitively identify. In the largest reported study on this topic to date, we found OSA severity to be an independent predictor of glycaemic health, adding to a growing body of evidence that OSA has an independent association with insulin resistance and impaired glucose tolerance.

The Portable Monitoring Task Force of the American Academy of Sleep Medicine reviewed available evidence and met to develop consensus recommendations on the use of PM in the diagnosis and management of patients with OSA. The AASM Board of Directors approved this clinical guideline. Previous reviews have concluded that PM should be used only on a limited basis. The Task Force identified additional appropriate indications and usage of PM within parameters guided by the followin

Our findings suggest that changes in sleep-related behaviors between baseline and the end of CBTI may influence rates of medication discontinuation following SMT. While stability of rise time and stability of TIB at the end of CBTI did not predict medication use outcomes, change in  stability did predict outcomes—both with regard to use of BZD-related hypnotics and use of any medication or substance for sleep. Specifically, individuals who increased the stability of their ris

Current Food and Drug Administration (FDA) guidelines for surgical management with UAS include adult patients with an AHI between 15 and 65, failure of other treatment modalities, and a BMI less than 32 kg/m 2 at the time of surgery. BMI eligibility criteria were initially established by the FDA-approved STAR clinical trial in which patients with a BMI greater than 32 were excluded These recommendations are still routinely followed despite the unknown effectiveness of UAS in

Our analyses observed that the prevalence of OSA was substantially higher in persons who had been infected with COVID-19 or who had been...

In the current study, we demonstrated that, compared to participants who sleep an average of 7 hours per day, those who sleep ≥ 9 hours...

Sleep medicine, by its very nature, is a technology-driven medical specialty. From polysomnography and HSAT to PAP machines and...

In a large cohort of patients referred to a sleep laboratory and systematically evaluated with full in-laboratory PSG we found that GOAL,...

The Average duration of CPAP use (4-7 hours/night) seems disappointing. However, these results have to be compared with those obtained by...

Globally, approximately 150 million people live at altitudes >2500 m. Ambient hypoxia makes highlanders chronically hypoxaemic, which...

In this large population-based cross-sectional study we observed that nightly awakenings and intradaily variability of the 24-hour...

The main finding of this study is that the combination of atomoxetine and dronabinol administered for 2 weeks at escalating doses may...