The present study shows that serum levels of the inflammatory markers IL-6, hs-CRP, and G-CSF are increased in patients with COPD and OVS compared with healthy controls. Furthermore, levels of IL-6, hs-CRP, and G-CSF were higher in participants with COPD and OVS compared with OSA alone. Second, we showed that participants with OVS have higher systemic inflammation levels as measured by leukocytes and neutrophils levels than COPD and OSA alone. Third, we observed no major impact of PAP therapy...

Observations that Organisms adapt their physiology and behavior to the time of the day in a circadian fashion have been documented for a long time and are commonly agreed to have begun with the observation of leaf and flower movements in plants. For example, the leaves of mimosa plants close at night and open during the day. In 1729, the French astronomer Jean Jacques d’Ortous de Mairan placed a mimosa plant in the dark and observed that the leaves still opened and closed rhythmically at the...

This randomized controlled clinical trial demonstrates that in the hands of sleep medicine specialists an integrated home-based portable monitoring strategy for both diagnosis and treatment of patients with moderate to severe OSA is not inferior to a laboratory-based strategy. The home-based strategy appears equivalent in terms of outcomes important to patients: acceptance of therapy, time to treatment, reduced hypersomnolence, improved functional outcomes (both generic and disease-specific),...