The key finding of this study was that ESRD patients with sleep apnoea had a mean total body ECFV 2.6 L greater than those without sleep apnoea. While there was a higher proportion of males and older subjects in the sleep apnoea group compared to the no sleep apnoea group, there was no difference in BMI between the groups. Age and total body ECFV index were the only independent factors associated with the presence of sleep apnoea, and furthermore, total body ECFV index was the only factor that
correlated independently with sleep apnoea severity as assessed by the AHI. Another important finding in this study was that the sleep apnoea group had higher LECFV, TECFV and NECFV in the evening, and a greater overnight reduction in LECFV than the no sleep apnoea group. These results are in keeping with evidence that fluid overload is an important factor in the pathogenesis of sleep apnoea in chronic kidney disease and in ESRD.