This study investigated the associations between sleep IIV and cortisol diurnal rhythm, as well as an index of multi system physiological dysregulation. Findings showed that after controlling for covariates, more variable sleep timing and duration was associated with flatter cortisol diurnal slope, over and above the effects of their respective mean values. More variable sleep quality was associated with higher multi system physiological dysregulation; however, these associations were no longer significant after controlling for covariates. Later mean BT was the only sleep IIM significantly associated with higher AL in both unadjusted and adjusted models. Therefore, in a sample of community-dwelling adults, there is evidence for higher sleep IIV to be associated with alterations in cortisol diurnal rhythm as a proximal outcome but not with higher multi system physiological dysregulation as a distal outcome.
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