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  • Writer's pictureS-Med

OSA during rapid eye movement sleep in patients with diabetic kidney disease

Recent studies have shown that obstructive sleep apnea is associated not only with hyperglycemia but with actual diabetes-related endpoints, including diabetic kidney disease (DKD). On the other hand, although obstructive sleep apnea during rapid eye movement(REM) and non-REM sleep leads to different cardiometabolic and neurocognitive complications, whether REM-related obstructive sleep apnea is associated with DKD is not clear because all previous studies used home sleep apnea testing, which does not distinguish between REM- and non-REM–apnea-hypopnea index.

In this study, we showed that overall apnea-hypopnea index and REM–apnea-hypopnea index, but not non-REM–apnea-hypopnea index,were independently correlated with DKD after adjusting several known risk factors for DKD. Obstructive sleep apnea, especially during REM sleep, is a potential risk factor for DKD.


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